Tigecycline-induced acute pancreatitis: about two cases and review of the literature
(2012) Acta Clinica Belgica (Multilingual Edition) —
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- Abstract
- Tigecycline (formerly CAR-936, Tygacyl) is the first glycylcycline antibiotic available for clinical use. It has an expanded broad-spectrum antibiotic activity. Phase III studies have identified gastrointestinal side-effects, especially nausea and vomiting, as the most common adverse events. Few cases of acute pancreatitis (AP) have been described in the literature. We report two new cases of mild tigecycline-induced pancreatitis. Tigecycline was given for soft-tissue infection in both cases. Symptoms such as nausea, vomiting and mostly abdominal pain occurred within 5 days after starting Tigecycline. Pancreatic enzymes elevation occurred five to six days after initiation of treatment, and resolved within a week after drug-discontinuation. Diagnosis of mild pancreatitis was confirmed after performing CT-Scan of the abdomen in both cases. We take this opportunity to review the literature about this potentially serious side-effect induced by tigecycline.
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Marot, J.-C., Jonckheere, S., Munyentwali, H., Belkhir, L., Vandercam, B., & Yombi, J. C. (2012). Tigecycline-induced acute pancreatitis: about two cases and review of the literature. Acta Clinica Belgica (Multilingual Edition). https://hdl.handle.net/2078.5/98090