Transabdominal amnioinfusion treatment of severe oligohydramnios in preterm premature rupture of membranes at less than 26 gestational weeks.

De Santis, Marco;Scavo, Maria;Noia, Giuseppe;Masini, Lucia;Caruso, Alessandro;et.al.
(2003) Fetal Diagnosis and Therapy : clinical advances and basic research — Vol. 18, n° 6, p. 412-417 (2003)

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Authors
  • De Santis, Marco
    Author
  • Scavo, Maria
    Author
  • Noia, Giuseppe
    Author
  • Masini, Lucia
    Author
  • Piersigilli, Fiammettaorcid-logoUCLouvain
    Author
  • Caruso, Alessandro
    Author
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Abstract
OBJECTIVE: To evaluate the efficacy of transabdominal amnioinfusion on feto-neonatal and maternal morbidity and feto-neonatal mortality. METHODS: We studied 71 patients with preterm premature rupture of membranes (pPROM) at <26 weeks of gestational age. Thirty-four patients were managed expectantly and 37 underwent serial transabdominal amnioinfusion with saline every 7 days in case of persistent oligohydramnios. RESULTS: Latency period pPROM delivery, week of delivery (26.0 vs. 22.4, p<0.001), neonatal weight (922 vs. 602, p<0.01) and the percentage of intrauterine fetal survival were higher in treated than in control groups (64.8 vs. 32.3%, p<0.01). In amnioinfusion-treated patients, we did not note a higher rate of complications from infection during both pregnancy and puerperium. In the amnioinfusion group, fluid loss within 6 h after infusion is the main variable in predicting pulmonary hypoplasia and neonatal survival. CONCLUSIONS: Our data suggest that amnioinfusion seems to be a low fetal and maternal risk technique that modifies the natural history of pPROM, improving fetal intrauterine stay and survival.
Affiliations
  • Catholic University of Sacred Heart - (Italy) RomeNeonatal Intensive Care Unit

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De Santis, M., Scavo, M., Noia, G., Masini, L., Piersigilli, F., Romagnoli, C., & Caruso, A. (2003). Transabdominal amnioinfusion treatment of severe oligohydramnios in preterm premature rupture of membranes at less than 26 gestational weeks. Fetal Diagnosis and Therapy : clinical advances and basic research, 18(6), 412-417. https://doi.org/10.1159/000073134 (Original work published 2003)