Identifying Antigens Recognized by Cytolytic T Lymphocytes on Tumors.
(2019) Methods in molecular biology (Clifton, N.J.) — Vol. 1988, p. 159-186 (2019)
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- Abstract
- Identification of antigenic peptides recognized by cytolytic T lymphocytes (CTL) is a prerequisite for the development of targeted cancer immunotherapy approaches. This chapter provides a global approach for the identification of peptides recognized by CTL. It implies the identification of the HLA molecule presenting the peptide as well as the design and screening of a cDNA library derived from the tumor cells. Methods used for the identification of spliced peptides on tumors are also described.
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Vigneron, N., Stroobant, V., Ma, W., Michaux, A., & Van den Eynde, B. (2019). Identifying Antigens Recognized by Cytolytic T Lymphocytes on Tumors. Methods in molecular biology (Clifton, N.J.), 1988, 159-186. https://doi.org/10.1007/978-1-4939-9450-2_13 (Original work published 2019)