Intra-arterial hepatic fotemustine for the treatment of liver metastases from uveal melanoma : experience in 101 patients.
(2006) Annals of Oncology — Vol. 17, n° 4, p. 578-583 (2006)
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- Abstract
- BACKGROUND: Exclusive liver metastases occur in up to 40% of patients with uveal melanoma associated with a median survival of 2-7 months. Single agent response rates with commonly available chemotherapy are below 10%. We have investigated the use of fotemustine via direct intra-arterial hepatic (i.a.h.) administration in patients with uveal melanoma metastases. PATIENTS AND METHODS: A total of 101 patients from seven centers were treated with i.a.h. fotemustine, administered intra-arterially weekly for a 4-week induction period, and then as a maintenance treatment every 3 weeks until disease progression, unacceptable toxicity or patient refusal. RESULTS: A median of eight fotemustine infusions per patient were delivered (range 1-26). Catheter related complications occurred in 23% of patients; however, this required treatment discontinuation in only 10% of the patients. The overall response rate was 36% with a median overall survival of 15 months and a 2-year survival rate of 29%. LDH, time between diagnosis and treatment start and gender were significant predictors of survival. CONCLUSIONS: Locoregional treatment with fotemustine is well tolerated and seems to improve outcome of this poor prognosis patient population. Median survival rates are among the longest reported and one-third of the patients are still alive at 2 years.
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Peters, S., Voelter, V., Zografos, L., Pampallona, S., Popescu, R., Gillet, M., Bosshard, W., Fiorentini, G., Lotem, M., Weitzen, R., Keilholz, U., Humblet, Y., Piperno-Neumann, S., Stupp, R., & Leyvraz, S. (2006). Intra-arterial hepatic fotemustine for the treatment of liver metastases from uveal melanoma : experience in 101 patients. Annals of Oncology, 17(4), 578-583. https://doi.org/10.1093/annonc/mdl009 (Original work published 2006)