Pregnancy Outcomes After Kidney Transplantation and Long-Term Evolution of Children: A Single Center Experience

(en) BACKGROUND: Pregnancies in women who underwent kidney transplants are at high risk compared with the general population. METHODS: In this study, we aimed to retrospectively assess the obstetrical complications, delivery outcomes, and impact of pregnancy on kidney allograft function in a single-center cohort of kidney transplant recipients (KTRs). We provide data regarding the long-term evolution of children. RESULTS: Thirty-two KTRs underwent a total of 57 pregnancies between 1994 and 2010. Fourteen pregnancies (24 %) did not survive caused by miscarriages (n = 9), stillborn (n = 1), ectopic pregnancies (n = 2), and medical abortion (n = 2). Live birth occurred in 76% of pregnancies. Delivery was by cesarean in 66%. The mean gestational age was 30.45 ± 11.3 weeks and 65% of newborns were premature. A low birth weight <2500g was noted in 46%. Obstetric complications were de novo hypertension in 4%, pre-eclampsia in 9%, and gestational diabetes in 2%. The 5- and 10-year post-delivery death-censored graft loss rates were 3.1% and 12.5%, respectively. Data on 21 children were collected via a self-questionnaire. After a median follow-up time of 17 years, they appeared in good medical and psychological health. None of them suffered from chronic disease (especially uronephrological condition) or was taking chronic medication. CONCLUSIONS: Long-term evolution of children born to women who underwent kidney transplants seems favorable. Pregnancies in KTRs are successful in two-thirds of cases but are at increased risk of prematurity, delivery by cesarean, and low birth weight.

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Devresse, A., Jassogne, C., Hubinont, C., Debiève, F., De Meyer, M., Mourad, M., Darius, T., Buemi, A., Goffin, E., & Kanaan, N. (2022). Pregnancy Outcomes After Kidney Transplantation and Long-Term Evolution of Children: A Single Center Experience. Transplantation Proceedings, 54(3), 652-657. https://doi.org/10.1016/j.transproceed.2022.01.019 (Original work published 2022)