Rôles de l’inflammation et de l’apoptose dans la perturbation du dialogue cœur-poumon : applications particulières à la mort cérébrale
(2016)
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- Abstract
- Brain death is associated with heart dysfunction and acute lung injury. We investigated the involvement of inflammation and apoptosis in three animal models of right ventricle dysfunction associated with pulmonary hypertension. We developed a new brain-death model reproducing the conditions of a brain hemorrhage. In this model, we studied the pathobiological and pathophysiological mechanisms involved in these dysfunctions and using methylprednisolone pretreatment. Brain death is associated with right ventricular dysfunction and neurogenic pulmonary edema with a strong link between these dysfunctions and activation of inflammatory and apoptotic process. The functional entity “right ventricle - lung” seems particularly affected by brain death. Corticosteroids prevent these disturbances by a vasodilatory effect and partial control of inflammation and apoptosis.
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Belhaj, A. (2016). Rôles de l’inflammation et de l’apoptose dans la perturbation du dialogue cœur-poumon : applications particulières à la mort cérébrale. https://hdl.handle.net/2078.5/183283