Crystal structure of peroxiredoxin 5 and its use for design of structural homologues.

Declercq, Jean-Paul;Evrard, Christine;Clippe, André;Van Der Stricht, Delphine;Knoops, Bernard;et.al.
(2002)

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  • Declercq, Jean-PaulUCLouvain
    Inventor
  • Evrard, ChristineUCLouvain
    Inventor
  • Clippe, AndréUCLouvain
    Inventor
  • Van Der Stricht, DelphineUCLouvain
    Inventor
  • Bernard, AlfredUCLouvain
    Inventor
  • Knoops, BernardUCLouvain
    Inventor
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Abstract
The present invention relates to a crystal comprising a PRDX5 protein in crystalline form, wherein said PRDX5 protein in crystalline form has the tetragonal space group symmetry P41 21 2.The invention further relates to a method for synthesizing a homologue of said crystal or an active binding site pocket , wherein said method comprises(a) providing the coordinates of the active binding site pocket of PRDX5, defined by residues of Table 2 and structure coordinates in Table 1, to a computer modeling system,(b) designing a homologue of said crystal or said active binding site pocket;(c) synthesizing said homologue,(d) optionally screening said homologue in a peroxidase activity assay for determining its catalytic activity, and(e) if desired, determining whether said compound inhibits oxidation in an antioxidant activity assay.
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Declercq, J.-P., Evrard, C., Clippe, A., Van Der Stricht, D., Bernard, A., & Knoops, B. (2002). Crystal structure of peroxiredoxin 5 and its use for design of structural homologues. (Patent No. WO/2002/061063). https://hdl.handle.net/2078.5/255453