Brain leukotriene C4 binding sites are S-alkylglutathione binding sites

Goffinet, André;Nguyen, Ahn
(1989) European Journal of Pharmacology — Vol. 161, n° 1, p. 99-101 (1989)

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  • Goffinet, AndréUCLouvain
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  • Nguyen, Ahn
    Author
Abstract
Leukotriene C4 binding to mouse brain membranes was readily displaced by S-alkylglutathione derivatives, with the affinity of the test compound increasing as the alkyl chain length increases. S-decylglutathione was as potent as leukotriene C4. These data suggest that brain membrane leukotriene C4 binding sites are S-alkylglutathione binding sites, possibly microsomal glutathione transferase.
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Goffinet, A., & Nguyen, A. (1989). Brain leukotriene C4 binding sites are S-alkylglutathione binding sites. European Journal of Pharmacology, 161(1), 99-101. https://doi.org/10.1016/0014-2999(89)90186-6 (Original work published 1989)