Beta-3 Adrenoreceptor Agonist Mirabegron Improves Right Ventricular Function in a Rat Monocrotaline-Induced Pulmonary Hypertension Model.

Mendes-Ferreira, Pedro;Tielemans, Birger;Wagenaar, Allard;Bouzin, Caroline;Belge, Catharina;et.al.
(2026) Pulmonary Circulation — Vol. 16, n° 1, p. e70232 (2026)

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Abstract
Considering the beta-3 adrenoceptor agonist, mirabegron, may display vasodilator and cardioprotective properties, we investigated the therapeutic potential of mirabegron in monocrotaline-induced pulmonary hypertension in rats. High-dose mirabegron improved right ventricular function, and endothelium-dependent relaxation in isolated rat pulmonary arteries, suggesting that mirabegron may be beneficial in pulmonary arterial hypertension.
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Mendes-Ferreira, P., Tielemans, B., Wagenaar, A., Bouzin, C., Adão, R., Pokreisz, P., De Mulder, D., Leite-Moreira, A., Brás-Silva, C., Balligand, J.-L., Dessy, C., Delcroix, M., Quarck, R., & Belge, C. (2026). Beta-3 Adrenoreceptor Agonist Mirabegron Improves Right Ventricular Function in a Rat Monocrotaline-Induced Pulmonary Hypertension Model. Pulmonary Circulation, 16(1), e70232. https://doi.org/10.1002/pul2.70232 (Original work published 2026)