Une injection d’endotoxine bactérienne comme facteur déclenchant d’asthme éosinophilique.
(2016) Revue des Maladies Respiratoires — Vol. 33, n° 3, p. 261-263 (2016)
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- (en) [Bacterial endotoxin as a trigger for eosinophilic asthma] INTRODUCTION: Lipopolysaccharide is a component of the outer membrane of gram-negative bacteria. It plays an important role in asthma as an adjuvant to allergens in activating the airway epithelium. CASE REPORT: Following treatment of a cutaneous mycosis by injection of endotoxin from Salmonella (Pyrogenalum), a 49-year-old non-smoking man developed an acute bronchitis followed by persistent cough, sometimes productive of sputum. Clinical examination was unremarkable. Lung function tests showed airway obstruction, FEV1 54% predicted, partly reversible with salbutamol, and exhaled NO was increased to 73.5 ppb. There was a moderate blood eosinophilia ranging from 540 to 890 per mm(3) (7.4 to 9.6%). Lung CT scan showed no parenchymal or bronchial abnormalities, and ENT examination showed nasal polyposis. CONCLUSION: Besides its critical adjuvant role in the development of asthma when inhaled, this case suggests that endotoxin can also provoke asthma when administered systemically.
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Bodlet, A., Mouthuy, J., & Pilette, C. (2016). Une injection d’endotoxine bactérienne comme facteur déclenchant d’asthme éosinophilique. Revue des Maladies Respiratoires, 33(3), 261-263. https://doi.org/10.1016/j.rmr.2015.05.008 (Original work published 2016)