Hyperhomocysteinemia and diabetic macroangiopathy: guilty or innocent bystander?. A literature review of the current dilemma
(2007) Diabetes & Metabolic Syndrome : clinical research & reviews — Vol. 1, n° 1, p. 53-59 (2007)
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- Abstract
- Background: It is established from a large corpus of clinical studies that even moderately elevated plasma total homocysteine levels are associated with an increased risk for cardiovascular disease, in non-diabetic and in type 2 diabetic individuals. However, recent prospective interventions trials aimed at decreasing plasma homocysteine concentrations using vitamin supplementation (folic acid, Vitamin B-12, Vitamin B-6) were unable to demonstrate a clear preventive benefit on cardiovascular events. In this view, hyperhomocysteinemia could rather represent a marker of vascular risk than a true risk factor per se, as previously strongly hinted at. Objectives: The aim of this review is to analyse the pro- and contradictory data concerning a potential pathogenic role of hyperhomocysteinemia in the development of atherosclerosis, in particular in patients with type 2 diabetes, who are at high risk of developing macroangiopathy. Conclusions: Hyperhomocysteinemia could be a marker of atherosclerosis rather than a causal factor. © 2006 Diabetes India.
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Buysschaert, M., Preumont, V., & Hermans, M. (2007). Hyperhomocysteinemia and diabetic macroangiopathy: guilty or innocent bystander?. A literature review of the current dilemma. Diabetes & Metabolic Syndrome : clinical research & reviews, 1(1), 53-59. https://doi.org/10.1016/j.dsx.2006.11.013 (Original work published 2007)