Rôle des changements de [Ca2+]c dans le contrôle de la sécrétion de glucagon par le glucose et les modulateurs des canaux KATP
(2022)
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- Authors
- Supervisors
- Gilon, Patrick
- Abstract
- Islets of Langerhans are mainy composed of α-, β- and δ-cells secreting glucagon, insulin and somatostatin, respectively, the latter being inhibitory of the two other hormones. Glucose stimulates insulin and SST secretions by a well-known mechanism including the closure of ATP-sensitive K+ channels (KATP) and a rise in the free cytosolic Ca2+ concentration ([Ca2+]c). Sulfonylureas are used to treat diabetes because they stimulate insulin secretion by closing KATP channels. However, the mechanisms by which glucose and sulfonylureas act on α-cells are still poorly understood and are the subject of this thesis. Sulfonylureas control α-cells by two mechanisms, a direct stimulatory effect by elevating [Ca2+]c and an indirect inhibitory effect via SST. Glucose stimulates α-cells independently of SST at low concentration but inhibits α-cells by recruiting SST at high concentration.
- Affiliations
Citations
Singh, B. (2022). Rôle des changements de [Ca2+]c dans le contrôle de la sécrétion de glucagon par le glucose et les modulateurs des canaux KATP. https://hdl.handle.net/2078.5/109568