Passive diffusion of polymeric surfactants across lipid bilayers.
(2007) Journal of Controlled Release — Vol. 120, n° 1-2, p. 79-87 (2007)
Files
10981.pdf
Restricted Access - Adobe PDF
- 351.88 KB
Details
- Authors
- Abstract
- Self-assembling polymeric surfactant, mmePEG(750)P(CL-co-TMC) [monomethylether poly(ethylene glycol)(750)-poly(caprolactone-co-trimethylene carbonate)], increases drug solubility and crosses an enterocyte monolayer both in vitro and in vivo. The aims of the present work were to investigate whether mmePEG(750)P(CL-co-TMC) polymers can diffuse passively through lipid bilayer using parallel artificial membrane permeability assay (PAMPA) and affect membrane properties using liposomes as model. The mmePEG(750)P(CL-co-TMC) polymer was able to cross by passive diffusion an enterocyte-mimicking membrane in PAMPA at concentration which did not perturb membrane integrity. A weak rigidification associated with a low increase in permeability of liposomal lipid bilayers was observed. These data suggest that polymeric surfactants can cross the lipid membrane by passive diffusion and interact with lipid bilayers.
- Affiliations
Citations
Mathot, F., Schanck, A., Van Bambeke, F., Ariën, A., Noppe, M., Brewster, M., & Préat, V. (2007). Passive diffusion of polymeric surfactants across lipid bilayers. Journal of Controlled Release, 120(1-2), 79-87. https://doi.org/10.1016/j.jconrel.2007.03.015 (Original work published 2007)