Liver transplantation for neuroendocrine neoplasms liver metastases
(2025) Transplant oncology : a frontier in multidisciplinary cancer care — ISBN: [9780443219016], pages 63-78, accepted/in-press
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- Abstract
- Liver transplantation (LT) can be proposed for a selected group of patients with Neuroendocrine neoplasm liver metastases (NELM) that fulfill the well-established selection criteria. Indeed, outcomes of LT for NELM have improved after the introduction of such criteria in the mid-2000s, like the Milan criteria. However, it is necessary to refine the process of selecting patients who are eventually eligible for transplantation and also for liver resection, taking into account the most recent advances in procedures such as the three-dimension imaging and robotic approach. A better understanding of the tumor molecular profiling may be useful in characterizing tumor biology and behavior and could be incorporated into the therapeutic decision-making process. Alternative techniques such as Split, LDLT (classical technique or RAPID-ALDAPT variation) should be offered to NELM transplant candidates. Despite a high rate of post-transplant recurrence, such lesions should be treated aggressively using a multidisciplinary approach with a combination of therapies
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Coubeau, L., & Bonaccorsi Riani, E. (2025). Liver transplantation for neuroendocrine neoplasms liver metastases. In edited by: Maen A. Abdelrahim (ed.), Transplant oncology : a frontier in multidisciplinary cancer care (p. pages 63-78). https://doi.org/10.1016/b978-0-443-21901-6.00006-9