Adult T-type lymphoblastic lymphoma: treatment advances and prognostic indicators.
(2017) Experimental Hematology — Vol. 51, p. 7-16 (2017)
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- Abstract
- T-cell lymphoblastic lymphoma (T-LBL) is a rare, aggressive neoplasm of precursor T cells that occurs mostly in adolescents and young adults. In this review, we describe the treatment of adult T-LBL with a focus on recent advances using pediatric-inspired acute lymphoblastic leukemia regimens, which have greatly improved outcome. We also discuss the development of prognostic indicators for T-LBL, especially oncogenetic factors, that can identify patients at higher risk of relapse and should help further extend T-LBL patient survival. Pediatric-inspired acute lymphoblastic leukemia regimens have the potential to become the treatment of choice for adult T-LBL, and their use might also reduce the need for other long-standing T-LBL interventions, particularly mediastinal irradiation and stem cell transplantation.
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Lepretre, S., Graux, C., Touzart, A., Macintyre, E., & Boissel, N. (2017). Adult T-type lymphoblastic lymphoma: treatment advances and prognostic indicators. Experimental Hematology, 51, 7-16. https://doi.org/10.1016/j.exphem.2017.04.002 (Original work published 2017)