Precore Mutant Chronic Hepatitis-b in An Autochtonous Belgian Population - a Study of 10 Patients
(1995) Acta Clinica Belgica (Multilingual Edition) — Vol. 50, n° 3, p. 144-148 (1995)
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- Abstract
- The mode of contamination, presentation, clinical evolution and liver histology of 10 native Belgian patients with chronic hepatitis B likely due to a peculiar viral strain, the so called precore mutant hepatitis B virus were reviewed. This viral strain first described in Southern European regions is characterized by a mutation of a single base change at nucleotide 1896 in the preterminal codon of the precore region which creates a stop codon that prevents the production of HBeAg. In this setting, abnormal liver biochemistry and active viral replication as evidenced by HBV DNA positivity often coincides with a serological profile similar to that observed in healthy HBsAg carriers. Our data indicate that chronic hepatitis related to such a viral strain may be observed in a native Belgian population. This unusual presentation of chronic hepatitis B should thus be kept in mind when interpreting atypical sero-biochemical features, evaluating the risk of infectivity and the potential benefit of antiviral therapy.
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Citations
Kanyinda, JM., Horsmans, Y., Cornu, C., & Geubel, A. (1995). Precore Mutant Chronic Hepatitis-b in An Autochtonous Belgian Population - a Study of 10 Patients. Acta Clinica Belgica (Multilingual Edition), 50(3), 144-148. https://hdl.handle.net/2078.5/89685 (Original work published 1995)