Anti-GPVI (HY101) activates platelets in a multicolor flow cytometry panel.
(2022) Platelets (London) — Vol. 33, n° 7, p. 1096-1099 (2022)
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- Abstract
- The platelet transmembrane receptor GPVI can be assessed together with other platelet membrane markers in a whole blood multicolor flow cytometry panel. The advantage of combining multiple antibodies in a single tube is the possibility of distinguishing multiple platelet subgroups. In this short communication, we describe an activation problem encountered with anti-GPVI, clone HY101. Activation of platelets was seen after the addition of anti-GPVI in a flow cytometry panel, highlighted by the expression of the activation markers CD62P, PAC-1, CD63, and CD107a. This was also confirmed by platelet aggregation studies.
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van Dievoet, M.-A., Brusa, D., Octave, M., Horman, S., & Stephenne, X. (2022). Anti-GPVI (HY101) activates platelets in a multicolor flow cytometry panel. Platelets (London), 33(7), 1096-1099. https://doi.org/10.1080/09537104.2022.2027359 (Original work published 2022)