Density of Demodex-folliculorum in Rosacea - a Case-control Study Using Standardized Skin-surface Biopsy
(1993) British Journal of Dermatology — Vol. 128, n° 6, p. 650-659 (1993)
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- Abstract
- A standardized skin-surface biopsy (1 cm2) of the cheek was performed in 49 patients with rosacea [13 with erythematotelangiectatic rosacea (ETR), three with squamous rosacea (SR), 33 with papulopustular rosacea (PPR)], and 45 controls. A mean density of 0.7 Demodex folliculorum/cm2 was found in controls, 98% of whom had less than five Demodex/cm2. When all clinical types of rosacea were considered collectively, the density of Demodex was significantly higher in patients with rosacea than in controls (mean = 10.8/cm2; P < 0.001). When the various clinical types of rosacea were considered separately, Demodex density was statistically significantly higher than in controls only in the PPR patients (mean = 12.8/cm2; P < 0.001). The same type of comparison was also made for three other groups of subjects-patients with isolated inflammatory papules (n = 4), rhinophyma (n = 3), and HIV infection (n = 21), respectively: in these groups, the Demodex density did not differ significantly from controls. The present study demonstrates a high density of D. folliculorum in PPR, and supports its pathogenic role in the papulopustular phase of rosacea. The study suggests that standardized surface biopsy could be a useful diagnostic tool for PPR, with a 98% specificity when Demodex density is higher than 5/cm2.
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Forton, F., & Seys, B. (1993). Density of Demodex-folliculorum in Rosacea - a Case-control Study Using Standardized Skin-surface Biopsy. British Journal of Dermatology, 128(6), 650-659. https://doi.org/10.1111/j.1365-2133.1993.tb00261.x (Original work published 1993)