Regulation of plasma membrane aquaporins by SNARE proteins
(2013) 16th European Plant Endomembrane Research (ENPER) Meeting — Location: Ghent (27.August.2013)
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- Abstract
- Plant plasma membrane aquaporins (PIPs) are channels facilitating the passive movement of water and/or other small neutral solutes through biological membranes. A wide variety of mechanisms can regulate PIP trafficking to the plasma membrane and their activity or gating. These mechanisms usually involve physical interactions of PIPs with other proteins. We are characterizing specific interactions of several PIP isoforms with key molecular interactors in the secretory pathway belonging to the syntaxin (SYP) subfamily of SNARE (soluble N-ethylmaleimide-sensitive factor protein attachment protein receptor) proteins. We found that the post-Golgi traffic and water channel activity of PIP proteins is regulated by SYP121, a plasma membrane resident syntaxin involved in vesicle traffic, signaling and regulation of K+ channels. This SYP121-mediated regulation of PIP activity is conserved in both maize and Arabidopsis and supports the view that SYP121 plays a key role in the regulation of the cell osmotic homeostasis. Interaction of PIPs with SYP61, a Trans Golgi Network/Pre-Vacuolar Compartment-localized SNARE also appears to be necessary for the proper trafficking of PIPs to the plasma membrane. The physiological role of such interaction is currently under investigation. Altogether, these data support the view that interactions between specific SNARE proteins and PIP aquaporins modulate their trafficking route and therefore help regulate the plasma membrane water permeability.
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Hachez, C. (2013). Regulation of plasma membrane aquaporins by SNARE proteins. 16th European Plant Endomembrane Research (ENPER) Meeting, Ghent. https://hdl.handle.net/2078.5/201784