This dissertation undertakes a comprehensive exploration of Dominican knowledge of the Qur'an in the thirteenth century. Its aim is to understand how the Order engaged with the Qur'an: how it was interpreted, what uses were made of it, and how well it was known. To that end, the study focuses on three major Dominican friars and missionaries: Ramón Martí, William of Tripoli, and Riccoldo da Monte Croce. The first part of this three‑part dissertation begins with an investigation of the Dominican friars, their writings, and the earlier works that may have served as inspiration. This section is also dedicated to the tangible presence of the Qur’an in the sources, examining both the translations employed by the Dominican writers and their qur’anic quotes. The second part primarily examines the ways in which the Qur’an is used in Dominican polemical literature. It considers a broad range of topics, including criticisms of the Qur’an itself, its dogmas, and the figure of the Prophet Muhammad. The third part of the dissertation is devoted to Dominican attempts to define the nature and origins of the Qur’an. It examines and compares the different narratives found in the sources, aiming to shed to on both the general tendencies within the Order and the individual sensibilities of the authors.