POS0385 Oral systemic enzyme combination alleviates systemic inflammation, cartilage degradation, and pain in knee osteoarthritis–a proof-of-mechanism, randomized, double-blind, placebo-controlled study

Henrotin, Yves;Badot, Valerie;Urbin-Choffray, Didier;Brabant, C.;von Eynatten, Maximilian;et.al.
(2024) EULAR 2024 European Congress of Rheumatology — Location: (Austria) Vienna (12.June.2024)

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  • Henrotin, Yves
    Author
  • Badot, Valerie
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  • Urbin-Choffray, Didier
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  • Brabant, C.
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  • Dubuc, Jean-EmileUCLouvain
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  • von Eynatten, Maximilian
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Abstract
Background: Knee osteoarthritis (OA) is associated with substantial disability and impaired quality of life. Treatment aims at decreasing pain and improving function combining non-pharmacological (education, exercise, and weight reduction) and pharmacological modalities (topical, oral NSAIDs, and intraarticular corticosteroids). A challenge is to reduce the consumption of oral NSAIDs due to their side effects. Oral enzyme combination (OEC) therapy with bromelain, trypsin, and flavonoid rutin has proven to be efficacious in several painful musculoskeletal disorders and OA, but its mechanism of action is not fully known. [...]
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Henrotin, Y., Badot, V., Urbin-Choffray, D., Brabant, C., Dubuc, J.-E., Rau, S., Johansen, O. E., & von Eynatten, M. (2024). POS0385 Oral systemic enzyme combination alleviates systemic inflammation, cartilage degradation, and pain in knee osteoarthritis–a proof-of-mechanism, randomized, double-blind, placebo-controlled study. Annals of the rheumatic diseases, 83(Suppl 1), 395. https://doi.org/10.1136/annrheumdis-2024-eular.3713 (Original work published 2024)