Analysis of tuberculous meningitis cases by an immunoblotting assay based on a mycobacterial antigen complex
(1994) Clinical and Diagnostic Laboratory Immunology — Vol. 1, n° 3, p. 353-356 (1994)
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- Tuberculous meningitis cases were analyzed by an immunoblotting test based on Mycobacterium bovis BCG antigen complex A60. Anti-A60 immunoglobulin G (IgG) in cerebrospinal fluid (CSF) allowed early diagnosis, and concentrations decreased after recovery. In primary meningitis forms, anti-A60 IgGs were intrathecally synthesized and specific oligoclonal IgGs were present in CSF. In meningeal complications of pulmonary tuberculosis, there were matching titers of anti-A60 IgG in blood and CSF (mirror pattern). Correlation between CSF-restricted patterns and CSF pleocytosis was shown.
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Zou, Y. L., Van Antwerpen, M. P., Shi, G. Q., Chen, Q. X., Sindic, C., & Cocito, C. (1994). Analysis of tuberculous meningitis cases by an immunoblotting assay based on a mycobacterial antigen complex. Clinical and Diagnostic Laboratory Immunology, 1(3), 353-356. https://hdl.handle.net/2078.5/137326 (Original work published 1994)