Calcific Degeneration of CorMatrix 4 Years After Bicuspidization of Unicuspid Aortic Valve.

Mosala Nezhad, Zahra;Baldin, Paméla;Poncelet, Alain;El Khoury, Gebrine
(2017) The Annals of Thoracic Surgery — Vol. 104, n° 6, p. e431-e433 (2017)

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Abstract
We report the long-term outcomes of a 12-year-old boy who underwent bicuspidization of a severely stenotic unicuspid aortic valve with CorMatrix small intestinal submucosal extracellular matrix (CorMatrix Cardiovascular, Roswell, GA). CorMatrix supported favorable immediate surgical and echocardiographic outcomes and maintained stable growing functional dynamics for 2 years. At 52.5 months in situ, however, the valve failed with severe calcification, fibrosis, and retraction necessitating a redo operation. Reconstructive operations with CorMatrix are feasible, but this result questions its capacity for constructive remodeling in left-sided valve repair.
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Mosala Nezhad, Z., Baldin, P., Poncelet, A., & El Khoury, G. (2017). Calcific Degeneration of CorMatrix 4 Years After Bicuspidization of Unicuspid Aortic Valve. The Annals of Thoracic Surgery, 104(6), e431-e433. https://doi.org/10.1016/j.athoracsur.2017.07.040 (Original work published 2017)