Validation of a preclinical spinal safety model: effects of intrathecal morphine in the neonatal rat.

Westin, B David;Walker, Suellen M;Deumens, Ronald;Grafe, Marjorie;Yaksh, Tony L
(2010) Anesthesiology — Vol. 113, n° 1, p. 183-199 (2010)

Files

Westin2010Anesthesiology.pdf
  • Restricted Access
  • Adobe PDF
  • 2.11 MB
Request a copy

Details

Authors
  • Westin, B David
    Author
  • Walker, Suellen M
    Author
  • Deumens, RonaldUCLouvain
    Author
  • Grafe, Marjorie
    Author
  • Yaksh, Tony L
    Author
Abstract
The therapeutic ratio for intrathecal morphine (toxic dose/antinociceptive dose) was at least 300 at P3 and at least 20 at P21 (latter doses limited by side effects). These data provide relative efficacy and safety for comparison with other analgesic preparations and contribute supporting evidence for the validity of this preclinical neonatal safety model.
Affiliations

Citations

  • APA
  • Chicago
  • FWB

Westin, B. D., Walker, S. M., Deumens, R., Grafe, M., & Yaksh, T. L. (2010). Validation of a preclinical spinal safety model: effects of intrathecal morphine in the neonatal rat. Anesthesiology, 113(1), 183-199. https://doi.org/10.1097/ALN.0b013e3181dcd6ec (Original work published 2010)