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Authors
Supervisors
Baeck, Marie
 ;
Dumoutier, Laure
Abstract
Chronic spontaneous urticaria (CSU) is a chronic inflammatory skin disease characterized by pruritic urticarial wheals and/or swelling, named angioedema. Immunological mechanisms implicated in lesions occurrence are not well-known. A defect in self-tolerance (referred as autoimmunity) is present in a subset of patients. In this prospective work, we have studied some autoimmune markers in a large cohort of patients with CSU. We have also studied the expression of some cytokines and have found that IL-6, IL-1β and IL-24 are present and are possibly involved in CSU lesions development. Cytokines are molecules implicated in communication between cells and more particularly immune cells. Since cytokine blocking therapeutics are effective in some inflammatory and autoimmune diseases, identifying cytokines implicated in CSU is a major therapeutic challenge in this disease.
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De Montjoye, L. (2019). Immunological aspects of chronic spontaneous urticaria. https://hdl.handle.net/2078.5/170437