Challenges to medications development in treating alcohol dependence: An international perspective,
(2004) Alcohol and Alcoholism — Vol. 39 (2004)
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- Authors
Lehert, Philippe 
- Abstract
- (en) Few medications for treating alcohol dependence exist. Greater partnership is needed between academia and the pharmaceutical industry to develop, licence and market efficacious medications for treating alcohol dependence. Methodologies that span the divide between preclinical and large-scale clinical studies need to be developed in order to provide sufficient information on safety, toleration, drug-interaction profile and efficacy, with which to guide development decisions. Due to the heterogeneous nature of alcohol dependence, the effort of developing an efficacious medication is likely to be enhanced by clearer choices about the characteristics of the population. Careful consideration of potential mechanism of action of the putative therapeutic medication should enable the appropriate choice of drinking endpoint. The pharmaceutical industry in collaboration with academia might need to develop new approaches to determining appropriate treatment endpoints with regulatory bodies.
- Affiliations
Louvain School of Management
Citations
Littleton, J., Mann, K., Anton, R., Lehert, P., & De Witte, P. (2004). Challenges to medications development in treating alcohol dependence: An international perspective,. Alcohol and Alcoholism, 39. https://hdl.handle.net/2078.5/128525 (Original work published 2004)