Hépatotoxicité de la chimiothérapie systémique administrée dans le traitement des métastases hépatiques d'origine cool-rectale
(2016)
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- Authors
- Supervisors
- Gigot, Jean-François
- Abstract
- Liver resection is the gold standard for the treatment of colorectal liver metastases however, 10-20% of patients are initially resectable. Several therapeutic approaches have been adopted to improve the rate of resectability. These therapies include the use of efficient chemotherapeutic agents. The resulting downstaging or downsizing of liver metastasis, have led to an improved chance of curative liver resection in these patients. These chemotherapeutic drugs however, have been incriminated in the induction of pathological parenchymal lesions. The objectives of this work are to: 1. to evaluate the prevalence of these liver pathological lesions in treated patients and their clinical impact on liver resection. 2. to identify the predictive factors of their occurrence. 3. to evaluate the impact of these chemotherapy agents on liver regeneration and 4. to study the role of the addition of monoclonal antibodies on the prevalence and on the severity of these pathological lesions.
- Affiliations
Citations
Hubert, C. (2016). Hépatotoxicité de la chimiothérapie systémique administrée dans le traitement des métastases hépatiques d’origine cool-rectale. https://hdl.handle.net/2078.5/182835