Efficient Construction of Polycyclic Derivatives via a Highly Selective Cu(I)-Catalyzed Domino Reductive-Aldol Cyclization.

Deschamp, Julia Olivia;Riant, Olivier
(2009) Organic Letters —

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Abstract
A versatile methodology for the diastereo- and enantioselective domino reductive-aldol cyclizations is reported. By using a copper (I)/diphosphane ligand, various five- and six-membered rings were generated with good to excellent diastereo- and enantioselectivities (cis:trans up to 100:0 and ee up to 95%).
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Deschamp, J. O., & Riant, O. (2009). Efficient Construction of Polycyclic Derivatives via a Highly Selective Cu(I)-Catalyzed Domino Reductive-Aldol Cyclization. Organic Letters. Submitted. https://doi.org/10.1021/ol802879f