Synthesis, characterization, anti-trypanosomal activity and toxicity against Artemia salina Leach of thiobenzamides and derivatives
(2012) Journal of Applied Pharmaceutical Science — Vol. 2, n° 6, p. 62-66 (2012)
Files
No attached file found for this publication.
Details
- Authors
- Abstract
- This work aims to synthesize, characterize of thioamides benzaldehyde and 4-(dimethylamino)benzaldehyde and assess their in votrotrypanocidal activity and totoxicity. The Willgerodt-Kindler reaction preferred for the synthesis of thioamides morpholin-4-yl (phenyl) methanethione 1 and [4-(dimethylamino) phenyl]-(morpholin-4-yl) methanethione 2, is catalyzed with montmorillonite K-10 and in a microwave oven. The structures of the thioamides were characterized and confirmed by IR spectrometry, nuclear magnetic resonance (<sup>1</sup>H and <sup>13</sup>C NMR) and mass spectrometry (MS) Their trypanocidal activity was evaluated in the blood stream form of the strain of Trypanosoma brucei brucei 427 using the "Lilit, Alamar Blue" (Baltz et al., 1985; Hirumi et al., 1994; Räz et al., 1997) and cytotoxicity on brine shrimp larvae (Artemia salina Leach) using the method of Michael et al. (1956) resumed by Vanhaecke et al. (1981) and Sleet and Brendel (1983). The compounds1 (IC<sup>50</sup>> 483.09 μM) and 2 (IC<sup>50</sup>> 400 μM) have weak trypanocidal activities. However the larvae were sensitive to 2 (LD<sup>50</sup> = 214 ± 9 μM) and therefore it could be used in cancer treatment.
- Affiliations
Citations
Agnimonhan, F. H., Ahoussi, L., Kpoviessi, D. S. S., Gbaguidi, F. A., Kapanda Nankwa, C., Bero, J., Hannaert, V., Quetin-Leclercq, J., Moudachirou, M., Poupaert, J., & Accrombessi, G. C. (2012). Synthesis, characterization, anti-trypanosomal activity and toxicity against Artemia salina Leach of thiobenzamides and derivatives. Journal of Applied Pharmaceutical Science, 2(6), 62-66. https://doi.org/10.7324/JAPS.2012.2601 (Original work published 2012)