Deciphering the role of SGLT1 and SMIT1 in the pathophysiology of the heart

Ferté, Laura
(2021)

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Authors
  • Ferté, LauraUCLouvain
    author
Supervisors
Beauloye, Christophe
 ;
Bertrand, Luc
Abstract
This thesis project aims to decipher the role of sodium-glucose co-transporter (SGLT)1 and SMIT1 in the heart. First, we showed that glucose uptake, glycogen content, facilitative glucose transporters (GLUTs) and cardiac hypertrophy were all unchanged in our SGLT1 Δex1KO model. We demonstrated that high concentrations of phlorizin exert aspecific effects on GLUT transporters independently of SGLT1. More importantly, we reported the expression of a SGLT1 truncated variant in mouse and human hearts. Ultimately, we examined the role of SMIT1 in a hyperglycemic chronic environment, via injection of streptozotocin (STZ). Our preliminary results on RNA-seq data showed dysregulated genes associated to heart failure and cardiac fibrosis in our SMIT1 KO mice. These data on SGLT1 and SMIT1 open new perspectives on their roles in cardiac pathophysiology.
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Ferté, L. (2021). Deciphering the role of SGLT1 and SMIT1 in the pathophysiology of the heart. https://hdl.handle.net/2078.5/107622