Gut microbiome composition is associated with long-term disability worsening in multiple sclerosis
(2023) Gut Microbes — Vol. 15, n° 1, p. 2180316 (2023)
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- Predicting the long-term outcome of multiple sclerosis (MS) remains an important challenge to this day. As the gut microbiota is emerging as a potential player in MS, we investigated in this study whether gut microbial composition at baseline is related to long-term disability worsening in a longitudinal cohort of 111 MS patients. Fecal samples and extensive host metadata were collected at baseline and 3 months post-baseline, with additional repeated neurological measurements performed over (median) 4.4 y. Worsening (with EDSS-Plus) occurred in 39/95 patients (outcome undetermined for 16 individuals). The inflammation-associated, dysbiotic Bacteroides 2 enterotype (Bact2) was detected at baseline in 43.6% of worsened patients, while only 16.1% of non-worsened patients harbored Bact2. This association was independent of identified confoun-ders, and Bact2 was more strongly associated with EDSS-Plus than neurofilament light chain (NfL) plasma levels. Furthermore, using fecal sampling performed 3 months post-baseline, we observed Bact2 to be relatively stable, suggesting its potential use as a prognostic biomarker in MS clinical practice. ARTICLE HISTORY
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Devolder, L., Pauwels, A., Van Remoortel, A., Falony, G., Vieira-Silva, S., Nagels, G., De Keyser, J., Raes, J., & D’Hooghe, M. B. (2023). Gut microbiome composition is associated with long-term disability worsening in multiple sclerosis. Gut Microbes, 15(1), 2180316. https://doi.org/10.1080/19490976.2023.2180316 (Original work published 2023)