[Control of liver carbohydrate and lipid metabolism by cell volume.]
(1995) 12th Congress of the Societe-Francaise-d-Endocrinologie — Location: TOULOUSE(France) (8.September.1994)
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- Abstract
- Certain amino acids such as glutamine and proline stimulate liver glycogen synthesis and lipogenesis. This implies cell swelling and leads to the activation of glycogen synthase and acetyl-CoA carboxylase by a common mechanism. This mechanism results from the cell response to swelling and involves a fall in intracellular concentration of chloride ions and an increase in intracellular concentration of glutamate and aspartate. These ions indeed regulate the protein phosphatases that activate glycogen synthase and acetyl-CoA carboxylase.
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Citations
Hue, L. (1995). [Control of liver carbohydrate and lipid metabolism by cell volume.]. Annales d’Endocrinologie, 56(6), 599-601. https://hdl.handle.net/2078.5/86122 (Original work published 1995)