Gene expression changes in uterine myomas in response to ulipristal acetate treatment.
(2018) Reproductive BioMedicine Online — Vol. 37, n° 2, p. 224-233 (2018)
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Courtoy, Guillaume 
- Abstract
- (en) RESEARCH QUESTION: Does ulipristal acetate (UPA) modify the expression of genes related to apoptosis or the extracellular matrix in uterine myomas and are any modifications associated with a clinical response? DESIGN: Targeted analysis of 176 apoptosis- or extracellular-matrix-related genes was conducted using polymerase chain reaction (PCR) arrays. Relevant results were validated by quantitative PCR. Four groups were established: responsive short-term (one course, n = 9), responsive long-term (two to four courses, n = 9), non-responsive (n = 9), and the control group who was not given any hormone therapy (n = 9). The clinical response was monitored by medical imagery and considered significant when volume reduction was greater than 25%. RESULTS: Compared with untreated myomas, significant changes in expression of four genes were found in UPA-treated myomas. Gene expression of integrin subunit beta 4 was repressed by UPA treatment (fold change [FC] = -12.50, P < 0.001, q < 0.001), tenascin-C expression was downregulated in UPA-responsive patients (FC = -2.50, P = 0.010, q = 0.090), survivin was repressed in short-term UPA-responsive tumours (FC = -7.69, P < 0.001, q = 0.010), and catenin delta 2 gene expression was upregulated in non-responsive myomas (FC = +7.36, P < 0.001, q = 0.010). CONCLUSION: This characterization provides the first molecular distinction between myomas responsive or non-responsive to UPA treatment.
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Citations
Courtoy, G., Donnez, J., Ambroise, J., Arriagada, P., Luyckx, M., Marbaix, E., & Dolmans, M.-M. (2018). Gene expression changes in uterine myomas in response to ulipristal acetate treatment. Reproductive BioMedicine Online, 37(2), 224-233. https://doi.org/10.1016/j.rbmo.2018.04.050 (Original work published 2018)