Predictors of upper‐extremity motor outcomes after constraint‐induced therapy or bimanual training in children with cerebral palsy: A systematic review
(2025) Developmental Medicine & Child Neurology — Vol. 00, n° 00, p. 1-11 (2025)
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- Authors
Sogbossi, Emmanuel 
Mercier, Catherine
- Abstract
- Aim: To systematically review the factors that predict changes in upper-extremity motor function in response to constraint-induced movement therapy (CIMT) or bimanual training in children with cerebral palsy (CP). Method: The PubMed, Cochrane, Embase, Scopus, CINAHL, and PEDro databases were searched. Studies were included if predictor variables were measured at baseline and were linked to an upper-extremity motor function outcome after intervention. Studies investigating only neurophysiological biomarkers were excluded. Two independent reviewers conducted study selection, risk of bias assessment, data extraction, and synthesis. Results: The electronic search yielded 4317 articles, of which 23 were included (14 of 23 were randomized controlled trials). The most frequently studied factors were baseline motor outcomes (19 studies), age (19 studies), behavior (six studies), sex (six studies), and affected side (six studies), with inconsistent evidence to support an association with changes in upper-extremity motor function after CIMT or bimanual training. Cognitive deficits, somatosensory deficits, and mixed effects of predictive factors were rarely studied. Interpretation: Based on current evidence, it is inconclusive whether children with CP benefit from CIMT or bimanual training, regardless of their baseline upper-extremity motor function, age, sex, affected side, or behavior.
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Citations
Sogbossi, E., Zannou, E., Dossa, E., Houessou, C., Assogba, T., Longton, M., Everard, G., & Mercier, C. (2025). Predictors of upper‐extremity motor outcomes after constraint‐induced therapy or bimanual training in children with cerebral palsy: A systematic review. Developmental Medicine & Child Neurology, 00(00), 1-11. https://doi.org/10.1111/dmcn.70082 (Original work published 2025)