The role of the circadian clock in regulating mitochondrial dynamics and their impact on skeletal muscle function and metabolism

Carriel‐nesvara, Alfonso;Muñoz‐medina, Cristóbal;Deldicque, Louise;Castro‐sepulveda, Mauricio
(2025) The Journal of Physiology — Vol. -, n° -, p. - (2025)

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  • Carriel‐nesvara, Alfonsoorcid-logoLaboratorio de Fisiología del Ejercicio y Metabolismo (LABFEM), Escuela de Kinesiología, Facultad de Medicina Universidad Finis Terrae Santiago Chile
    Author
  • Muñoz‐medina, Cristóbalorcid-logoLaboratorio de Fisiología del Ejercicio y Metabolismo (LABFEM), Escuela de Kinesiología, Facultad de Medicina Universidad Finis Terrae Santiago Chile
    Author
  • Deldicque, LouiseInstitute of Neuroscience UCLouvain Ottignies‐Louvain‐la‐Neuve Belgium
    Author
  • Castro‐sepulveda, Mauricioorcid-logoLaboratorio de Fisiología del Ejercicio y Metabolismo (LABFEM), Escuela de Kinesiología, Facultad de Medicina Universidad Finis Terrae Santiago Chile
    Author
Abstract
figure legend Genetic disruption of core circadian clock proteins, particularly brain and muscle Arnt-like protein-1 (BMAL1), leads to altered mitochondrial dynamics and dysfunction, accompanied by reduced skeletal muscle quality. Key hallmarks include diminished muscle fibre size, impaired contractile strength, reduced exercise capacity and insulin resistance. The molecular mechanisms linking circadian clock proteins to mitochondrial dynamics regulation, and their role in muscle deterioration, remain unresolved. Created with BioRender.com (2025).
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Carriel‐nesvara, A., Muñoz‐medina, C., Deldicque, L., & Castro‐sepulveda, M. (2025). The role of the circadian clock in regulating mitochondrial dynamics and their impact on skeletal muscle function and metabolism. The Journal of Physiology, -(-), -. https://doi.org/10.1113/jp289019 (Original work published 2025)