Excitation-inhibition imbalances and their neurophysiological correlates in models of Alzheimer’s disease
(2017)
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- Authors
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- Abstract
- The major part of this thesis investigates Alzheimer’s disease using a well established amyloid beta based animal model. In addition to the known synaptic dysfunction, we document a detailed observation of seizures in old mice. The occurrence of seizures is further associated with a disequilibrium in the balance of the excitatory and inhibitory pathway in the central nervous system. In addition, this work documents imbalances in the excitatory and inhibitory transmission in in vitro and in vivo models recapitulating Tau pathology. Finally we have optimized the use of human derived induced pluripotent stem cell models for future analysis of neuronal dysfunction in the context of amyloid and tau pathology.
- Affiliations
UCLouvain SSS/IONS/CEMO - Pôle Cellulaire et moléculaire
Citations
Oyelami, A. (2017). Excitation-inhibition imbalances and their neurophysiological correlates in models of Alzheimer’s disease. https://hdl.handle.net/2078.5/92191