Recruiting the students to fight cancer: total synthesis of goniothalamin

Nahra, Fady;Riant, Olivier
(2015) Journal of Chemical Education — Vol. 92, n° 1, p. 179-182 (2015)

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Abstract
A modified total synthesis of (S)-goniothalamin is described for an advanced course in organic chemistry. This experiment gives students an opportunity to handle organometallic reagents and perform an enzymatic kinetic resolution and a metathesis reaction, all in the same synthesis.Furthermore, students learn flame-drying techniques for the manipulation of air-sensitive materials and high-performance liquid chromatography handling and analysis, thus strengthening their experimental knowledge.
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Nahra, F., & Riant, O. (2015). Recruiting the students to fight cancer: total synthesis of goniothalamin. Journal of Chemical Education, 92(1), 179-182. https://doi.org/10.1021/ed500457d (Original work published 2015)