Radiographic skeletal survey and radionuclide bone scan in Langerhans cell histiocytosis of bone.
(1996) Pediatric radiology — Vol. 26, n° 10, p. 734-738 (1996)
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- Abstract
- BACKGROUND: The lack of a consensus in the literature on the imaging strategy in Langerhans cell histiocytosis (LCH) bone lesions in childhood. OBJECTIVE: To evaluate the relative value of radionuclide bone scan (RBS) and radiographic skeletal survey (RSS) in the detection of LCH bone lesions, both in the initial work-up of the disease and during the follow-up period. MATERIALS AND METHODS: Ten children with bone lesions evaluated by means of RSS and RBS in a retrospective study (1984-1993). RESULTS: Fifty radiologically and/or scintigraphically abnormal foci were detected: 27 anomalies in the initial work-up (12 by both RSS and RBS, 8 by RSS only and 7 by RBS only) and 23 additional anomalies during follow-up (10 by both RSS and RBS, 10 by RSS only and 3 by RBS only). RSS+/RBS- lesions (n = 18) are more frequently encountered in the skull (P = 0.038), and more frequently lack radiologic signs of osteoblastic activity (P = 0.020), than RSS+/RBS+ lesions (n = 22). RSS-/ RBS+ abnormalities (n = 10) were most frequently insignificant. CONCLUSION: In the initial work-up both RSS and RBS should be carried out, while in the follow-up only RSS should be performed.
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Van Nieuwenhuyse, J. P., Clapuyt, P., Malghem, J., Everarts, P., Melin, J., Pauwels, S., Brichard, B., Ninane, J., Vermylen, C., & Cornu, G. (1996). Radiographic skeletal survey and radionuclide bone scan in Langerhans cell histiocytosis of bone. Pediatric radiology, 26(10), 734-738. https://hdl.handle.net/2078.5/55229 (Original work published 1996)