SLC22A1 /OCT1 genotype affects O-desmethyltramadol exposure in new-born infants.

Matic, Maja; de Wildt, Saskia N; Elens, Laure; de Hoon, Jan N; Annaert, Pieter; Tibboel, Dick; van Schaik, Ron Hn; Allegaert, Karel

doi:10.1097/FTD.0000000000000307

SLC22A1 /OCT1 genotype affects O-desmethyltramadol exposure in new-born infants.

Matic, Maja

;

de Wildt, Saskia N

;

Elens, Laure

;

de Hoon, Jan N

;

Allegaert, Karel

;et.al.

(2016) Therapeutic Drug Monitoring — Vol. EPub, n° AOP, p. 1 (2016)

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Authors

Matic, Maja
Author
de Wildt, Saskia N
Author
Elens, Laure
Author
de Hoon, Jan N
Author
Allegaert, Karel
Author

Abstract

This study determined whether SLC22A1 (encoding the organic cation transporter 1 (OCT1)) genotype could explain, in addition to postmenstrual age (PMA) (referring to gestational plus postnatal age) and CYP2D6 genotype, the tramadol (M) pharmacokinetic variability in early infancy.

Affiliations

UCLouvainSSS/LDRI - Louvain Drug Research Institute

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Matic, M., de Wildt, S. N., Elens, L., de Hoon, J. N., Annaert, P., Tibboel, D., van Schaik, R. H., & Allegaert, K. (2016). SLC22A1 /OCT1 genotype affects O-desmethyltramadol exposure in new-born infants. Therapeutic Drug Monitoring, EPub(AOP), 1. https://doi.org/10.1097/FTD.0000000000000307 (Original work published 2016)