Multi-component crystallization to alter solid-state properties
(2024)
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- Abstract
- This thesis explores the pivotal role of crystal engineering and multi-component crystallization in enhancing the physicochemical properties of active pharmaceutical ingredients (APIs) and other compounds. The research focuses on developing crystal engineering techniques to improve the stability of liquid compounds and addresses the challenges posed by unfavorable reaction equilibria in enzyme-catalyzed biosynthesis of enantiopure chiral amines through in situ product crystallization (ISPC). Special attention is devoted to overcoming the difficulties in crystallizing chiral compounds and optimizing separation methods based on salt formation and cocrystallization. The study successfully demonstrates the formation of new stable solid forms, enhances the conversion rates of transaminase-catalyzed reactions, and validates the potential of combining biocatalysis with crystallization to achieve highly enantioselective products. Ultimately, this thesis offers valuable insights into the application of crystal engineering for solving complex issues in pharmaceutical development and chiral compound synthesis, contributing to advancements in continuous process design. The research provides innovative solutions for the production of high-value chiral amines and other pharmaceutical compounds.
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Citations
Caro Garrido, C. F. (2024). Multi-component crystallization to alter solid-state properties. https://hdl.handle.net/2078.5/235442