Bridging the gap between tumor hypoxia and tumor response : assessing the value of imaging biomarkers to guide hypoxia-driven interventions in radiotherapy
(2015)
Files
Final_thesis_AnTRAN.pdf
Restricted Access - Adobe PDF
- 7.57 MB
Details
- Authors
- Supervisors
- Abstract
- Tumor hypoxia is known as a major cause of radioresistance. However, clinical practice actually does not integrate on a routine basis this factor in the definition of radiation protocols. This is in sharp contrast with the recent developments including the imaging techniques that monitor non-invasively tumor hypoxia, the emerging hypoxia-targeted therapies and the predictive tools to anticipate treatment outcome. Combining these advances offers the opportunity to translate knowledge on tumor hypoxia into an optimized, integrated and individualized anti-cancer treatment. In an attempt to bridge together tumor hypoxia and tumor response, the research presented here has consisted of three important tasks: validating the hypoxia imaging by 18F-FAZA PET; assessing the prognostic value of 18F-FAZA PET and its predictive potential to guide hypoxia-driven interventions in radiotherapy; assessing the utility of DW-MRI and 18F-FLT PET to early monitor the tumor response to irradiation.
- Affiliations
Citations
Tran, L. B. A. (2015). Bridging the gap between tumor hypoxia and tumor response : assessing the value of imaging biomarkers to guide hypoxia-driven interventions in radiotherapy. https://hdl.handle.net/2078.5/192961