Effects of riluzole on the evolution of focal cerebral ischemia: a magnetic resonance imaging study
(1997) Magma (New York, N.Y.) — Vol. 5, n° 3, p. 185-191 (1997)
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- The aim of this study was to investigate the effects of riluzole on the lesion induced by a permanent middle cerebral artery occlusion (MCAO) in rats. Riluzole at 4 or 8 mg/kg i.v. significantly reduced the cortical ischemic brain damage. With the most effective dose of 8 mg/kg, the time evolution of the lesion was assessed by T2-weighted magnetic resonance imaging (MRI) repeated on the same animals after MCAO. MRI obtained at 24, 48, and 72 hours after MCAO showed a progressive increase of the ischemic lesion, except in the cortex of the riluzole-treated rats (8 mg/kg i.v.). Furthermore, there was no difference between lesion volumes as measured by MRI or by histology. This study indicates that MRI may be a valuable method to quantify in vivo the neuroprotective profile of a drug.
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Mottet, I., Demeure, R., Rataud, J., Lucas, M., Wahl, F., Warscotte, V., Thiran, J.-P., Goudemant, J.-F., Maldague, B., Maloteaux, J.-M., & Stutzmann, J.-M. (1997). Effects of riluzole on the evolution of focal cerebral ischemia: a magnetic resonance imaging study. Magma (New York, N.Y.), 5(3), 185-191. https://doi.org/10.1007/BF02594581 (Original work published 1997)