Immunoradiometric assays of total renin and gonadotropins in serum during the menstrual cycle.
(1989) Fertility and sterility — Vol. 52, n° 2, p. 209-215 (1989)
Files
No attached file found for this publication.
Details
- Authors
- Abstract
- The contribution of the ovary to the circulating total renin pool is linked to its secretory activity in relation with its reproductive function. In a longitudinal study of 13 normal women, total renin levels measured in serum by an immunoradiometric assay were lower in the midfollicular phase (180 +/- 59 pg/ml) than in the midluteal phase (291 +/- 100 pg/ml). Peak levels were encountered 1 day after the luteinizing hormone (LH) surge (375 +/- 97 pg/ml). Rapid circhoral fluctuations were observed in all periods of the cycle, unrelated to the LH pulses. In case of ovarian function inhibition (induced by gonadotropin-releasing hormone agonists), total renin levels were lower than in the midfollicular phase (126 +/- 56 pg/ml). Low levels also were encountered in the prepubertal period (153 +/- 89 pg/ml). Very high levels (17,600 +/- 11,400 pg/ml) were found in follicular fluids from stimulated cycles. These results show that circulating total renin levels follow a complex pattern in which LH, but possibly also follicle-stimulating hormone and gonadal steroid hormones (estradiol and progesterone), may play a role.
- Affiliations
Citations
De Hertogh, R., Vankrieken, L., de Gasparo, M., & Thomas, K. (1989). Immunoradiometric assays of total renin and gonadotropins in serum during the menstrual cycle. Fertility and sterility, 52(2), 209-215. https://hdl.handle.net/2078.5/54001 (Original work published 1989)