Trisomy 11 in myeloid malignancies is associated with internal tandem duplication of both MLL and FLT3 genes.

Rege-Cambrin, Giovanna;Giugliano, Emilia;Michaux, Lucienne;Stul, Michel;Hagemeijer, Anne;et.al.
(2005) Haematologica — Vol. 90, n° 2, p. 262-264 (2005)

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Authors
  • Rege-Cambrin, Giovanna
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  • Giugliano, Emilia
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  • Michaux, LucienneUCLouvain
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  • Stul, Michel
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  • Hagemeijer, Anne
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Abstract
In 20 patients with myeloid malignancies and isolated trisomy 11 an internal tandem duplication of the MLL and FLT3 genes was observed in 41% and 31% of the cases, respectively; 80% of the FLT3+ cases showed MLL self-fusion. Concomitant presence of MLL and FLT3 anomalies could be relevant in determining the poor outcome of patients with acute myeloid leukemia with trisomy 11.
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Rege-Cambrin, G., Giugliano, E., Michaux, L., Stul, M., Scaravaglio, P., Serra, A., Saglio, G., & Hagemeijer, A. (2005). Trisomy 11 in myeloid malignancies is associated with internal tandem duplication of both MLL and FLT3 genes. Haematologica, 90(2), 262-264. https://hdl.handle.net/2078.5/99158 (Original work published 2005)