Identification and in vitro immunosuppressive activity of a SDZ-IMM-125 metabolite isolated from phenobarbital-induced rabbit liver microsomes

Dieden, R;Latinne, Dominique;Verbeeck, RK.;Maton, Nicole;Lhoëst, Georges
(1997) Xenobiotica : the fate of foreign compounds in biological systems — Vol. 27, n° 9, p. 933-949 (1997)

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  • Dieden, R
    Author
  • Latinne, DominiqueUCLouvain
    Author
  • Verbeeck, RK.
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  • Maton, NicoleUCLouvain
    Author
  • Lhoëst, Georges
    Author
Abstract
1. A metabolite of D-serine-cyclosporine A has been isolated from phenobarbital induced rabbit liver microsomes using hplc. 2. This metabolite was identified by FAB, electrospray mass spectrometry as well as nmr spectroscopy and is the result of metabolism of the vinylic methyl group of the 9-carbon amino acid unique to the cyclosporins, the first amino acid of this cyclic undecapeptide. This metabolite exhibits a significantly lower immunosuppressive activity than IMM-125 and CsA.
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Dieden, R., Latinne, D., Verbeeck, RK., Maton, N., & Lhoëst, G. (1997). Identification and in vitro immunosuppressive activity of a SDZ-IMM-125 metabolite isolated from phenobarbital-induced rabbit liver microsomes. Xenobiotica : the fate of foreign compounds in biological systems, 27(9), 933-949. https://doi.org/10.1080/004982597240109 (Original work published 1997)