Validation of Heel Stick Microsampling To Optimize Micafungin Doses in Neonates and Young Infants.
(2018) Antimicrobial Agents and Chemotherapy — Vol. 62, n° 10, p. e01199-18 [1-4] (2018)
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- Authors
Auriti, Cinzia 
Pai, Manjunath P
- Abstract
- Major gaps exist in our knowledge of antimicrobial pharmacokinetics in critically ill neonates and infants that require validated microsampling and bioanalysis methods to support therapeutic drug monitoring. We compared serially collected intravenous (i.v.) and heel stick capillary (HSC)-sampled plasma concentrations of micafungin (8 mg/kg) in eight infants born preterm with systemic candidiasis. The mean (standard deviation) micafungin area under the plasma concentration-time curve to infinity (AUC) was 316 (65.0) h · mg/liter based on HSC concentrations that strongly correlated ( = 0.92) with i.v. values to support dose adjustment.
- Affiliations
Bambino Gesù Children’s Hospital – (Italy) Roma Department of Medical and Surgical Neonatology
Citations
Auriti, C., Goffredo, B. M., Ronchetti, M. P., Piersigilli, F., Cairoli, S., Bersani, I., Dotta, A., & Pai, M. P. (2018). Validation of Heel Stick Microsampling To Optimize Micafungin Doses in Neonates and Young Infants. Antimicrobial Agents and Chemotherapy, 62(10), e01199-18 [1-4]. https://doi.org/10.1128/AAC.01199-18 (Original work published 2018)