Intraperitoneal urokinase and oral Rifampicin for asymptomatic persistent dialysate infection by coagulase-negative staphylococcus

Demoulin, Nathalie;Goffin, Eric
(2008) Peritoneal Dialysis International — Vol. 28, n° Supp. 4, p. S19 (2008)

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Abstract
Coagulase-negative staphylococcus (CoNS) is responsible for cases of refractory and relapsing peritonitis in peritoneal dialysis (PD) patients, probably by biofilm formation on the catheter. The ISPD recommends catheter removal in such cases. Urokinase has been used to dissolve the biofilm lining the PD catheter, thus favoring antibiotic efficacy. Rifampicin has shown its efficacy in penetrating CoNS biofilm.
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Demoulin, N., & Goffin, E. (2008). Intraperitoneal urokinase and oral Rifampicin for asymptomatic persistent dialysate infection by coagulase-negative staphylococcus. Peritoneal Dialysis International, 28(Supp. 4), S19. https://hdl.handle.net/2078.5/46626 (Original work published 2008)