Cytolytic response of human T cells against allogeneic small cell lung carcinoma treated with interferon gamma.
(1988) Cancer Immunology, Immunotherapy — Vol. 27, n° 3, p. 228-232 (1988)
Files
WEYNANTS_CII1988.pdf
Restricted Access - Adobe PDF
- 458.09 KB
Details
- Authors
- Abstract
- Human lymphocytes stimulated in vitro by allogeneic small cell lung carcinoma cell lines did not show any significant cytolytic activity against the stimulator tumor cells. However, a high level of lysis was observed when both stimulator and target small cell lung carcinoma cells were pretreated with interferon gamma, which increased considerably the expression of major histocompatibility class I molecules by these cells. The demonstration that small cell lung carcinoma cells can be lysed by cytolytic T lymphocytes, suggests that it will be feasible to study the autologous T cell response of patients against this tumor.
- Affiliations
Citations
Weynants, P., Wauters, P., Coulie, P., Van den Eynde, B., Symann, M., & Boon, T. (1988). Cytolytic response of human T cells against allogeneic small cell lung carcinoma treated with interferon gamma. Cancer Immunology, Immunotherapy, 27(3), 228-232. https://doi.org/10.1007/BF00205444 (Original work published 1988)