Bioactivity and hemocompatibility study of amorphous hydrogenated carbon coatings produced by pulsed magnetron discharge.
(2012) Journal of Biomedical Materials Research. Part A — Vol. 101, n° 6, p. 1800-1812 (2012)
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- Literature contains very few data about the potential biomedical application of amorphous hydrogenated carbon (a-C:H) thin films deposited by reactive pulsed magnetron discharge even so it is one of the most scalable plasma deposition technique. In this article, we show that such a C(2) H(2) pulsed magnetron plasma produces high quality coating with good hemocompatibility and bioactive response: no effect on hemolysis and hemostasis were observed, and proliferation of various cell types such as endothelial, fibroblast, and osteoblast-like cells was not affected when the deposition conditions were varied. Cell growth on a-C:H coatings is proposed to take place by a two-step process: the initial cell contact is affected by the smooth topography of the a-C:H coatings, whereas the polymeric-like structure, together with a moderate hydrophilicity and a high hydrogen content, directs the posterior cell spreading while preserving the hemocompatible behavior. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.
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Lopez-Santos, C., Colaux, J. L., Laloy, J., Fransolet, M., Mullier, F., Michiels, C., Dogné, J.-M., & Lucas, S. (2012). Bioactivity and hemocompatibility study of amorphous hydrogenated carbon coatings produced by pulsed magnetron discharge. Journal of Biomedical Materials Research. Part A, 101(6), 1800-1812. https://doi.org/10.1002/jbm.a.34489 (Original work published 2012)