Therapeutic hopes for CFTR-related recurrent pancreatitis: a case-series

Gohy, Sophie;Le, Anaïs;Sermet-Gaudelus, Isabelle;De Wachter, Elke;Scheers, Isabelle;et.al.
(2026) Journal of Cystic Fibrosis — Vol. 25, n° 3, p. 509-512 (2026)

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Abstract
The presence of CFTR variants increases the risk of pancreatitis in pancreatic sufficient people with cystic fibrosis (pwCF) or with CFTR-related disorder (pwCFTR-RD). Modulators have been showed to decrease pancreatitis episodes in pwCF presenting recurrent pancreatitis. Whether CFTR modulators are efficient to prevent recurrent episodes of pancreatitis in pwCFTR-RD is not known. We collected clinical, biological, imaging and CFTR functional data in 4 patients with recurrent pancreatitis and CFTR-RD, treated with CFTR modulators and assessed the efficacy of the treatment. With a follow-up of minimum 9 months, we found that ETI and ivacaftor reduced or even resolved the number of acute pancreatitis episodes
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Gohy, S., Le, A., Sermet-Gaudelus, I., De Wachter, E., Lhomme, A., Vermeulen, F., & Scheers, I. (2026). Therapeutic hopes for CFTR-related recurrent pancreatitis: a case-series. Journal of Cystic Fibrosis, 25(3), 509-512. https://doi.org/10.1016/j.jcf.2026.02.008 (Original work published 2026)